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AHV International - Animal Health Vision Concept & SolutionsAHV International – Animal Health Vision Concept & Solutions

AHV is a leading developer and knowledge centre within the agricultural sector with the Animal Health Vision Concept & Solutions.

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AHV QSI TECHNOLOGY

To develop our innovations, it is of vital importance to understand the role of quorum sensing in animal health.

With our knowledge of bacteria, quorum sensing and biofilms, we are able to block bacterial communication and influence their behaviour like biofilm formation. This is called quorum quenching (QQ).

Formation of biofilms are controlled by the quorum sensing (QS) signalling genes and their products. Various inhibitors/compounds are able to disturb the QS signalling cascade and used as alternative therapy for optimising biofilm-related challenges. Attenuation of bacterial QS signalling by molecules derived from plants possesses inhibitory activity against bacterial and fungal biofilms (Abranches J., 2011).

AHV QUORUM SENSING ANTAGONIST (QSI) TECHNOLOGY

To develop our innovations, it is vital to understand the role of quorum sensing (QS) in animal health.

With our knowledge of bacteria, QS and biofilms, we are able to block bacterial communication and influence their behaviour such as biofilm formation. This is called quorum quenching (QQ).

Formation of biofilms is controlled by the QS signalling genes and their products. Various inhibitors/compounds are able to disturb the QS signalling cascade and are used as alternative therapy for optimising biofilm-related challenges. Attenuation of bacterial QS signalling by molecules derived from plants possesses inhibitory activity against bacterial and fungal biofilms (Abranches J., 2011).

Biofilm formation

Bacteria form and maintain biofilm through the process of quorum sensing.

Biofilm eradication

AHV’s proprietary technology disrupts the quorum sensing process and eradicates biofilm structure.

Clearing

Without the “protection” of biofilm, pathogenic bacteria become susceptible to immune cells, reduces the need for antibiotics.

Figure 1: Our Fundamental lab research, our basis for our product development

AHV FUNDAMENTAL RESEARCH: BIOFILM ERADICATION STUDIES 

Our team of microbiologists is able to cultivate a wide range of bacterial biofilm in AHV’s BSL-2 laboratory. Via these bacterial biofilms, AHV is able to select the plant molecules that are able to avoid biofilm formation (MBIC) or to eradicate existing biofilms (MBEC).

This research has led to our patent pending innovative anti-biofilm compounds, or QQs extracted from natural resources. With our wide range of innovations and solutions for animal health, AHV supports and empowers the farming community through new standards for animal health management and care. 

In multiple independent studies, mature biofilms (figure 2: Control dosage) were examined using different dosages (figure 3: High dosage) of the AHV QSI Technology active anti biofilm compounds. 

Figure 2: Untreated bacterial biofilm (AHV International, 2021)

Figure 3: Biofilm eradication with AHV QSI Technology active compounds (AHV International, 2021)

Bacterial biofilm visualized from the top in a Nikon confocal laser scanning microscope. Green signals represent the active bacteria, red signals represent inactive bacteria. The top panel resembles the control with untreated biofilm. The bottom panel shows biofilm treated with active AHV QSI Technology compounds. The results of the core AHV QSI Technology were measured after one day (figure 3). A clear reduction / breakdown of the biofilm was already established because of a high amount of inactive bacteria and a few active bacteria.

FROM RESEARCH TO PRODUCTS

Our AHV QSI Technology inhibits bacterial communication, avoids biofilm formation and reduces virulency. Our products promote the (natural) immune system of the body cells and support the animals’ energy and mineral metabolism.

Product strategy

Based on mode of action

Figure 4: AHV Product Strategy (AHV International, 2021)

Discover more about AHV

AHV Website Quorum Sensing

Quorum Sensing

We use the quorum sensing science to disrupt the communicatoin between selected bacteria.


Read more >

AHV Biofilm

Biofilm

Biofilm formation is mostly a survival strategy or defense mechanism for bacteria, who thus make use of the benefits of acting as a community.

Read more >

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AHV New Zealand

Waikato Innovation Park
1 Melody Lane
HAMILTON 3216
New Zealand
Tel: 0800 4 248 69

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Please choose your country or region below for specified information or view our corporate website:

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